bioRxiv / medRxiv
open access
Defining transcriptomic niches in human fibrotic lung with multi-sample spatial transcriptomics analysis using the MAPLE algorithm
Idiopathic pulmonary fibrosis (IPF) is an age-related lung disease marked by patchy parenchymal fibrosis that disrupts gas exchange and leads to respiratory failure. Single-cell RNA-seq studies have revealed cellular heterogeneity in IPF, but the spatial contexts underlying alveolar epithelial cell
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