bioRxiv / medRxiv
open access
A Metacell Model of Single Cell RNA-seq Counts Yields a Gaussian Mixture Model in PCA Space
Single cell RNA sequencing (scRNAseq) has revolutionized cellular biology over the past decade. At its most basic, a scRNAseq dataset is a cell by gene matrix with entries giving the transcription count of a particular gene in a particular cell. A common workflow applies log-normalization and z-scor
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