HAL (France)
open access
Synthesis and Antischistosomal Activity Profile of Several Sub-Series of Redox-Active Lead 3-Benzylmenadiones─Investigations of the Modes of Action in Yeast
Abstract Three sub-series of 3-benzylmenadiones were discovered as new antischistosomal agents. The most potent representatives, called schistodiones, exhibited IC50 values <5 μM against larvae and ex vivoSchistosoma mansoni adult worms and moderate activity per os in the S. mansoni-infected mous
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