HAL (France)
open access
Hepatitis C virus NS3 helicase contributes to (−) strand RNA synthesis
Abstract Many positive strand RNA viruses encode helicases, but their distinct functions in viral replication cycles is poorly understood. Here, we identify a mutation in the helicase domain of HCV non-structural protein 3 (NS3h), D1467G, which specifically affects (−) strand synthesis, phenocopying
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