HAL (France)
open access
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia
The regulation of the hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channels in pacemaker myocytes is essential for maintaining physiological cardiac rhythm. HCN4 dysfunctional behavior is among the major factors contributing to sinus node disease, a primary cause of pacemaker implant
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