HAL (France)
open access
Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity
Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are hydrolases that specialize in the cleavage of esters such as acetylcholine. However, they can also cleave the carbamate group of certain drugs, such as rivastigmine. This leads to inhibition of these ChEs and preservation of acetylcho
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