Substrate-Independent Biophysical and Epistemic No-Go Theorems for Non-Physical Models of Mind

Traditional physicalist refutations of interactive dualism rely heavily on classical thermodynamic bounds, local field coupling limits, and General Relativistic energy constraints. Evaluating consciousness versus physical substrate dynamics within Cartesian field theory fundamentally misconstrues the ontological architecture of physical state transitions. By recasting the problem into Quantum Information Theory, Nielsen Complexity Geometry, Differential Information Geometry, and Holographic Entanglement Wedge Reconstruction, this paper establishes a substrate-independent framework governing extrinsic steering. Non-physical models are operationalized strictly via exclusion criteria and fundamental information constraints, bridging classical biology to quantum information limits as a upper-bound no-go theorem. The Ontological Gauge Invariant (ΩI) is introduced as a metric evaluating the causal agency of extrinsic controllers across arbitrary boundaries. It is proven that extrinsic steering without energetic signatures requires non-computable shortcuts on the Riemannian manifold of unitaries, violating both the Unitary Complexity Bound and boundary-bulk duality in tensor networks. Furthermore, non-interactive epiphenomenalism is addressed through the Self-Stultification Theorem: any causally inert entity satisfies I (Sbrain; Φext) ≡ 0, rendering all physical utterances regarding its existence epistemically self-refuting. Consequently, interactive, non-interactive, and epiphenomenal extrinsic models are universally excluded in all physical and computational substrates.