Trauma Dissociation, Neuroinflammation, and Hemispheric Segregation: A Comparative Theoretical Framework Linking Schizophrenia and Alzheimer’s Disease

This paper proposes a theoretical framework for exploring possible relationships between early childhood trauma, emotional dissociation, and neurobiological pro cesses associated with psychiatric and neurodegenerative conditions. Drawing from the Computational Agent Psychopathology Emergence (C.A.P.E.) architecture and a conceptual distinction between Primary and Secondary Personality, the framework examines how unintegrated affective material, referred to here through the psycho dynamic concept of the “Shadow,” may influence cognition, emotional regulation, and subjective experience. The paper compares schizophrenia and Alzheimer’s disease as distinct conditions that may, at a conceptual level, raise questions about the relationship between psychological integration, cognitive functioning, and biological vulnerability. It also discusses neuroinflammation as a possible area of investigation rather than as an established causal bridge between traumatic memory and neurodegeneration. A first-person account of traumatic memory re-emergence and subsequent psy chological integration is presented as a subjective observation that motivated the theoretical inquiry. The experience cannot establish the presence of neuroinflamma tion or demonstrate a causal relationship between trauma integration and neurological disease. The proposed framework is therefore exploratory and does not constitute a clinical model, a diagnostic system, or a validated explanation of schizophrenia or Alzheimer’s disease. The central aim is to distinguish the psychological interpretation of trauma inte gration from claims requiring independent neurobiological evidence, while identifying questions that could guide future interdisciplinary research.