HAL (France)
open access
Caractérisation phénotypique des mutations de P53 dans le carcinome hépatocellulaire
Le suppresseur de tumeur p53 est muté dans plus de 50% de cancers humains. Bien que p53 soit très étudié, les conséquences précises de ses mutants dans le processus oncogénique et les mécanismes moléculaires sous-jacents restent partiellement caractérisés. Cela s'explique par les fonctions pléiotrop
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