HAL (France)
open access
Anti-HLA class I IgG subclasses skew platelet activation mechanisms in transfusion refractoriness
Patients requiring recurrent platelet transfusions are subject to platelet transfusion refractoriness (PTR), a therapeutic failure due to rapid clearance of transfused platelets from the circulation. One major cause of PTR is the presence in the recipient of multiple IgG directed against allogeneic
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