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2,4-Diaminopyrimidines active against Plasmodium falciparum via the inhibition of haemozoin formation: In-silico discovery and SAR Investigation
Efforts towards the eradication of malaria have been countered by the frequent emergence of Plasmodium resistance to clinical drugs, necessitating the tactical development of next-generation antimalarials. Haemozoin formation, the mechanism by which Plasmodium detoxifies haem during its asexual bloo
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