Machine learning-assisted optimization of injectable silk fibroin hydrogels functionalized with decellularized extracellular matrix and mesenchymal stromal cell secretome.

Silk fibroin (SF) hydrogels are promising injectable scaffolds for wound repair, but optimizing their multi-parametric gelation remains challenging due to complex formulation-processing interactions. We developed a bioinspired gelation strategy combining potassium-driven β-sheet nucleation with soni