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ATRX deficiency drives aberrant type I interferon signalling through cGAS-dependent transcriptional dysregulation

El-Daher, Marie-Thérèse A. et al.
PubMed Central · Reports · License: CC BY 4.0
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The X-linked α-thalassaemia intellectual disability syndrome (ATRX) protein is a chromatin remodeller involved in transcriptional regulation and genome stability. While the importance of ATRX in development and malignancy is well recognised, its role in innate immunity is less well defined. Here we
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