THE RELATİONSHİP BETWEEN VİTAMİN D LEVELS AND PLASMA ATHEROGENİC INDEX (PAI): A CROSS-SECTİONAL STUDY

THE RELATİONSHİP BETWEEN VİTAMİN D LEVELS AND PLASMA ATHEROGENİC INDEX (PAI): A CROSS-SECTİONAL STUDY | Zenodo Skip to main Communities My dashboard Log in Sign up Zenodo is currently experiencing slowness and intermittent outages due to heavy automated traffic from bots and AI crawlers. We are aware of the problem, and our team is focused on stabilizing the service. Thank you for your patience. Published April 30, 2026 | Version v1 Journal article Open THE RELATİONSHİP BETWEEN VİTAMİN D LEVELS AND PLASMA ATHEROGENİC INDEX (PAI): A CROSS-SECTİONAL STUDY Authors/Creators Özge Pınarbaşlı Akçam*1, Ersin Akçam2 Description Background/aim: This study aimed to evaluate plasma atherogenic index (PAI) values in patients with vitamin D deficiency and to investigate the relationship between 25-hydroxyvitamin D levels and PAI. Materials and Methods: This retrospective cross-sectional study was approved by the Non-Interventional Scientific Research Ethics Committee of Afyonkarahisar Health Sciences University (07.03.2025, No: 2025/4). A total of 352 consecutive patients with available lipid profile and 25(OH)D measurements in 2024-2025 were included. PAI was calculated as log₁₀(TG/HDL-C). Vitamin D deficiency was defined as <20 ng/mL. Statistical analyses included Student’s t-test, Mann-Whitney U test, Pearson correlation, and multiple linear regression (p < 0.05). Results: 76.1% of the patients were female, and the mean age was 46.8 ± 16.1 years. The mean 25(OH)D level was 17.4 ± 9.2 ng/mL, and 61% had vitamin D deficiency. PAI was significantly higher in the deficiency group (0.41 ± 0.26 vs 0.29 ± 0.21 in the sufficient group; p < 0.001). A negative correlation was found between 25(OH)D level and PAI (r = -0.29, p < 0.001). In multiple regression analysis, vitamin D deficiency remained an independent predictor of PAI (β = -0.24, p = 0.004) after adjustment for age, sex, and diabetes. Conclusion: Vitamin D deficiency is independently associated with a higher plasma atherogenic index. Vitamin D screening and supplementation may contribute to cardiovascular risk management, particularly in patients with metabolic risk factors. Files 5 WJAPS 421.pdf Files (537.8 kB) Name Size Download all 5 WJAPS 421.pdf md5:1b274ca6c9e60fc04f71ac00dcf9e276 537.8 kB Preview Download Additional details Identifiers ISSN 3049-3013 Related works Is referenced by Journal article:

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(ISSN) References Holick MF. Vitamin D deficiency. N Engl J Med., 2007; 357(3): 266-81. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008; 117(4): 503-11. Dobiásová M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: contribution to diagnosis and therapy. Clin Chem Lab Med., 2006; 44(11): 1297-302. Dobiasova M. AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek., 2006; 52(1): 64-71. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci., 2009; 338(1): 40-4. Al Mheid I, Quyyumi AA. Vitamin D and cardiovascular disease: controversy unresolved. J Am Coll Cardiol, 2017; 70(1): 89-100. Li YC, et al. Vitamin D: a negative endocrine regulator of the renin-angiotensin system. J Clin Invest, 2002; 110(2): 229-38. Pittas AG, et al. Vitamin D and cardiometabolic health. Nat Rev Endocrinol, 2010; 6(4): 217-25. Agbaht K, et al. Vitamin D status in Turkey: a systematic review. Turk J Med Sci., 2022; 52(4): 1025-38. Vimaleswaran KS, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis. PLoS Med., 2013; 10(2): e1001383. Jorde R, Grimnes G. Vitamin D and metabolic health: a review. Eur J Clin Nutr., 2011; 65(6): 643-52. Forman JP, et al. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system. Hypertension, 2010; 55(4): 1001-7. Wimalawansa SJ. Non-musculoskeletal benefits of vitamin D. J Steroid Biochem Mol Biol, 2018; 175: 60-81. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc., 2013; 88(7): 720-55. Bouillon R, et al. Vitamin D and human health. Lancet Diabetes Endocrinol, 2019; 7(11): 862-74. Scragg R, et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease. JAMA Cardiol, 2017; 2(6): 608-16. Manson JE, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med., 2019; 380(1): 33-44. Barbarawi M, et al. Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals. JAMA Cardiol, 2019; 4(8): 765-76. Zhang Y, et al. Vitamin D deficiency and lipid profiles. Nutrients, 2020; 12(5): 1420. Miller NE, et al. Relation of triglyceride and highdensity lipoprotein cholesterol concentrations to plasma lipid transfer protein activity. Atherosclerosis, 1992; 92(2-3): 143-50. Holick MF, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011; 96(7): 1911-30. Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol, 2013; 28(3): 205-21. Kim YH, et al. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatr Allergy Immunol, 2016; 27(6): 580-90. 27 Views 11 Downloads Show more details All versions This version Views Total views 27 27 Downloads Total downloads 11 11 Data volume Total data volume 7.0 MB 7.0 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Keywords and subjects Keywords Vitamin D deficiency, plasma atherogenic index, cardiovascular risk. Details DOI DOI Badge DOI 10.5281/zenodo.19924088 Markdown [](https://doi.org/10.5281/zenodo.19924088) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19924088.svg :target: https://doi.org/10.5281/zenodo.19924088 HTML <a href="https://doi.org/10.5281/zenodo.19924088"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19924088.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19924088.svg Target URL https://doi.org/10.5281/zenodo.19924088 Resource type Journal article Publisher Zenodo Published in WORLD JOURNAL OF ADVANCE PHARMACEUTICAL SCIENCES, 3(5), 41-44, ISSN: 3049-3013, 2026. Languages English Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Copyright WJAPS Citation Export Technical metadata Created April 30, 2026 Modified April 30, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies

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