MOLECULAR-BIOCHEMICAL MECHANISMS OF METABOLIC CHANGES IN THYROID DISEASES

MOLECULAR-BIOCHEMICAL MECHANISMS OF METABOLIC CHANGES IN THYROID DISEASES | Zenodo Skip to main Communities My dashboard Log in Sign up Zenodo is currently experiencing slowness and intermittent outages due to heavy automated traffic from bots and AI crawlers. We are aware of the problem, and our team is focused on stabilizing the service. Thank you for your patience. Published May 5, 2026 | Version v1 Journal article Open MOLECULAR-BIOCHEMICAL MECHANISMS OF METABOLIC CHANGES IN THYROID DISEASES Authors/Creators Marupova, Malikabonu Ixtiyorovna (Editor) 1 Muxamedova, S.N. (Editor) 2 Show affiliations 1.

Faculty of Medical Pedagogy and Treatment, General Medicine program, Group 207. 2.

Scientific supervisor, Tashkent State Medical University, Department of Medical and Biological Chemistry, Medical Biology, Biophysics and Medical Informatics, Assistant, PhD Description This article provides a comprehensive analysis of the molecular and biochemical mechanisms of metabolic changes that occur in thyroid diseases. The thyroid gland plays a central role in ensuring the metabolic homeostasis of the body, and its functional disorders lead to profound biochemical changes at the level of the whole organism. In conditions such as hypothyroidism and hyperthyroidism carbohydrate, lipid and protein exchange violation not only clinical appearances shapes, maybe cell at the level mitochondrial dysfunction, oxidizing stress and alarm of the roads change with that it is related shown. T3 and T4 hormones nuclear receptors through gene expression The regulatory mechanisms, as well as their mitochondrial and nucleogenic effects, are described in detail. Immunometabolic correlations in autoimmune thyroiditis, particularly CD4+ and CD8+ T-lymphocytes, macrophages , and cytokines with the participation of inflammation cascades analysis done. From this except, thyroid hormone deiodinases through peripheral metabolism, selenoproteins and ATF-binder proteins role, also genetic and epigenetic of factors thyroid in pathologies importance discussion will be done. In the article Modern molecular-biochemical research methods and their prospects for application in clinical practice are also considered. This work aims to provide a deeper understanding of the molecular basis of thyroid pathologies. and new therapeutic approaches working to go out aimed at research determines the directions. Files 333-341.pdf Files (303.2 kB) Name Size Download all 333-341.pdf md5:211d008bc9c54a32409e645b279fa0a0 303.2 kB Preview Download Additional details References [1]Chaker L, Razvi S, Bensenor IM, Dear F, Pappas Oh, Peters RP. Hypothyroidism. Nat Rev. Dis Primers. 2022;8(1):30. [2]Say Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet. 2016;388(10047):906–918. [3]Mullur R, Liu YY, Brent Yes. Thyroid hormones regulation of metabolism. Physiology Rev. 2014;94(2):355–382. [4]Sinha R.A., Singh UK, Yen PM. Thyroid hormones regulation of liver lipid oath carbohydrate metabolism. Trends Endocrinol Metab. 2014;25(10):538–545. [5]Cheng SY, Leonard J.L., Davis PJ. Molecular aspects of thyroid hormones actions. Endocrinologist Rev. 2010;31(2):139–170. 34 Views 18 Downloads Show more details All versions This version Views Total views 34 34 Downloads Total downloads 18 18 Data volume Total data volume 6.1 MB 6.1 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Keywords and subjects Keywords thyroid gland, hypothyroidism, hyperthyroidism, metabolic disorders, molecular mechanisms, thyroid hormones, mitochondrial dysfunction, oxidative stress, autoimmune thyroiditis, deiodinases, signaling pathways. Details DOI DOI Badge DOI 10.5281/zenodo.20038589 Markdown [](https://doi.org/10.5281/zenodo.20038589) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.20038589.svg :target: https://doi.org/10.5281/zenodo.20038589 HTML <a href="https://doi.org/10.5281/zenodo.20038589"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.20038589.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.20038589.svg Target URL https://doi.org/10.5281/zenodo.20038589 Resource type Journal article Publisher Zenodo Published in Journal of Multidisciplinary Sciences and Innovations, 5(5), 333-341, ISSN: 2751-4390, 2026. Languages English Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created May 5, 2026 Modified May 5, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies

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