MORPHOLOGICAL FEATURES OF THE THYROID GLAND AFTER CHEMICAL BURNS OF THE DIGESTIVE TRACT AND THEIR CORRECTION UNDER EXPERIMENTAL CONDITIONS

MORPHOLOGICAL FEATURES OF THE THYROID GLAND AFTER CHEMICAL BURNS OF THE DIGESTIVE TRACT AND THEIR CORRECTION UNDER EXPERIMENTAL CONDITIONS | Zenodo Skip to main Communities My dashboard Log in Sign up Zenodo is currently experiencing slowness and intermittent outages due to heavy automated traffic from bots and AI crawlers. We are aware of the problem, and our team is focused on stabilizing the service. Thank you for your patience. Published April 29, 2026 | Version v1 Dataset Open MORPHOLOGICAL FEATURES OF THE THYROID GLAND AFTER CHEMICAL BURNS OF THE DIGESTIVE TRACT AND THEIR CORRECTION UNDER EXPERIMENTAL CONDITIONS Authors/Creators Komiljonova Oygul Olimjonovna (Contact person) 1 Show affiliations 1.

Department of Fundamental Medicine Asia International University Description Chemical burns of the digestive tract are severe pathological conditions that trigger not only local tissue injury but also systemic metabolic, inflammatory, and endocrine disturbances. Among endocrine organs, the thyroid gland is particularly sensitive to generalized stress and toxic injury because of its high vascularization, active protein synthesis, and close involvement in metabolic regulation. The present study was aimed at investigating the morphological and histochemical changes in the thyroid gland after experimental chemical burns of the digestive tract and evaluating the structural trends observed during correction. The investigation was carried out on white outbred rats, and thyroid tissue was examined using routine histological assessment with Van Gieson staining. The analysis focused on follicular architecture, colloid characteristics, the condition of follicular epithelium, stromal connective tissue, and the microcirculatory bed. The control group demonstrated preserved follicular organization, homogeneous colloid, cuboidal thyrocytes, and a delicate stromal framework, corresponding to a stable euthyroid structural pattern. After chemical injury, the thyroid gland showed follicular polymorphism, uneven colloid distribution, resorption phenomena, increased epithelial height, stromal thickening, and vascular congestion, indicating functional strain and the development of early pathological remodeling. In animals subjected to correction, the thyroid gland displayed partial restoration of follicular organization, improved colloid homogeneity, reduced epithelial hyperactivity, and attenuation of stromal and microvascular disturbances. The findings indicate that chemical burns of the digestive tract induce substantial morphofunctional alterations in the thyroid gland, whereas corrective intervention contributes to structural stabilization, although full normalization may not occur at the studied stage. The study supports the view that the thyroid gland may serve as a sensitive morphological marker of systemic injury and of the effectiveness of therapeutic correction. Files 1674-1682.pdf Files (807.9 kB) Name Size Download all 1674-1682.pdf md5:6f7dd52a559c91973fd759df8a540fc9 807.9 kB Preview Download Additional details References Ross, M. H., & Pawlina, W. Histology: A Text and Atlas. Junqueira, L. C., & Carneiro, J. Basic Histology: Text and Atlas. Gartner, L. P., & Hiatt, J. L. Color Atlas and Text of Histology. Guyton, A. C., & Hall, J. E. Textbook of Medical Physiology. Larsen, P. R., Kronenberg, H. M., Melmed, S., & Polonsky, K. S. Williams Textbook of Endocrinology. 82 Views 8 Downloads Show more details All versions This version Views Total views 82 82 Downloads Total downloads 8 8 Data volume Total data volume 6.5 MB 6.5 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Details DOI DOI Badge DOI 10.5281/zenodo.19882788 Markdown [](https://doi.org/10.5281/zenodo.19882788) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19882788.svg :target: https://doi.org/10.5281/zenodo.19882788 HTML <a href="https://doi.org/10.5281/zenodo.19882788"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19882788.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19882788.svg Target URL https://doi.org/10.5281/zenodo.19882788 Resource type Dataset Publisher Zenodo Published in INTERNATIONALMULTIDISCIPLINARYJOURNALFORRESEARCH&DEVELOPMENT, 13(04), 1674-1682, ISSN: 2394-6334, 2026. Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created April 29, 2026 Modified April 29, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies

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