[2303.09485] Variation of the relative biological effectiveness with fractionation in proton therapy: analysis of prostate cancer response Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Physics > Medical Physics arXiv:2303.09485 (physics) [Submitted on 16 Mar 2023 ( v1 ), last revised 24 Oct 2023 (this version, v3)] Title: Variation of the relative biological effectiveness with fractionation in proton therapy: analysis of prostate cancer response Authors: Juan Pardo-Montero , Miguel Pombar , Antonio Gómez-Caamaño , Simona Giordanengo , Isabel González-Crespo View a PDF of the paper titled Variation of the relative biological effectiveness with fractionation in proton therapy: analysis of prostate cancer response, by Juan Pardo-Montero and 4 other authors View PDF Abstract: Purpose: To present a methodology to analyze the variation of RBE with fractionation from clinical data of tumor control probability (TCP) and to apply it to study the response of prostate cancer to proton therapy. M&M: We analyzed the dependence of the RBE on the dose per fraction by using the LQ model and the Poisson TCP formalism. Clinical TCPs for prostate cancer treated with photon and proton therapy for conventional fractionation (2 Gy(RBE)x37 fractions), moderate hypofractionation (3 Gy(RBE)x20 fractions) and hypofractionation (7.25 Gy(RBE)x5 fractions) were obtained from the literature and analyzed. Results: The theoretical analysis showed three distinct regions with RBE monotonically decreasing, increasing or staying constant with the dose per fraction, depending on the change of ({\alpha}, \{beta}) values between photon and proton irradiation (the equilibrium point being at({\alpha}_p/\{beta}_p)=({\alpha}_X/\{beta}_X)({\alpha}_X/{\alpha}_p)). An analysis of the clinical data showed RBE values that decline with increasing dose per fraction: for low risk RBE=1.124, 1.119, and 1.102 for 1.82 Gy, 2.73 Gy and 6.59 Gy per fraction (physical proton doses), respectively; for intermediate risk RBE=1.119, and 1.102 for 1.82 Gy, and 6.59 Gy per fraction (physical proton doses), respectively. These values are nonetheless very close to the nominal 1.1 value. Conclusions: We presented a methodology to analyze the RBE for different fractionations, and we used it to study clinical data for prostate cancer. The analysis shows a monotonically decreasing RBE with increasing dose per fraction, which is expected from the LQ formalism and the changes in ({\alpha}, \{beta}) between photon and proton irradiation. However, the calculations in this study have to be considered with care as they may be biased by limitations in the modeling and/or by the clinical data set used for the analysis. Comments: Minor changes to match accepted manuscript; in press Medical Physics Subjects: Medical Physics (physics.med-ph) Cite as: arXiv:2303.09485 [physics.med-ph] (or arXiv:2303.09485v3 [physics.med-ph] for this version) https://doi.org/10.48550/arXiv.2303.09485 Focus to learn more arXiv-issued DOI via DataCite Journal reference: Medical physics 2023;50(11):7304-7312 Related DOI : https://doi.org/10.1002/mp.16783 Focus to learn more DOI(s) linking to related resources Submission history From: Juan Pardo-Montero [ view email ] [v1] Thu, 16 Mar 2023 17:02:35 UTC (619 KB) [v2] Mon, 2 Oct 2023 16:11:31 UTC (686 KB) [v3] Tue, 24 Oct 2023 14:30:22 UTC (686 KB) Full-text links: Access Paper: View a PDF of the paper titled Variation of the relative biological effectiveness with fractionation in proton therapy: analysis of prostate cancer response, by Juan Pardo-Montero and 4 other authors View PDF view license Current browse context: physics.med-ph < prev | next > new | recent | 2023-03 Change to browse by: physics References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... 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