Skip to main Communities My dashboard Log in Sign up Published April 13, 2026 | Version v1 Journal article Open Comprehensive annotation and analysis of human microproteins by human microprotein atlas platform Authors/Creators Kang, Boming (Data collector) 1 Cui, Chunmei (Supervisor) Show affiliations 1. Peking University Description Small open reading frames (sORFs) and their encoded microproteins are increasingly recognized as a widespread but poorly characterized component of the human proteome. Here we show a Human Microprotein Atlas (HMPA) platform (http://www.cuilab.cn/microaf) that integrates 617,462 human microproteins with sequence features, predicted three-dimensional structures, variant effect predictions, subcellular localization, essentiality, and bioactivity annotations. Structural analyses revealed substantial conformational diversity, and structure-based functional inference suggested roles in cellular regulation, signaling, and cell-cell communication. Deep learning-based analyses further prioritized microproteins with tissue-specific essentiality and enabled the prediction of diverse bioactivities across multiple functional categories. To support exploration of these data, we also provide an interactive web server with sequence-, structure-, and function-oriented search and analysis utilities. This resource provides a systematic framework for studying microprotein biology and supports the discovery of functional and therapeutically relevant microproteins. Files hmpa_anticancer_candidate_smorf197461_interactions.csv Files (8.4 GB) Name Size hmpa_anticancer_candidate_smorf197461_interactions.csv md5:b4686264f183e956633eb30b4c4d6b0b 10.1 MB Preview Download hmpa_anticancer_candidate_smorf230599_interactions.csv md5:8fdaf0272e535c6689488e31f36959b1 10.5 MB Preview Download hmpa_bioactivity_metadata.csv md5:6847f026614c914f31baf743fea9f39b 37.1 kB Preview Download hmpa_bioactivity_model_performance.csv md5:4dce07635fcb3594764c5a351116c8a1 394.4 kB Preview Download hmpa_bioactivity_predictions.pkl md5:90aeca24d795bb95fe14fafd72696900 1.1 GB Download hmpa_essentiality_pic_scores.pkl md5:ba0fc9de082f39273a7f235dbb626645 5.9 GB Download hmpa_function_deepfri_biological_process.pkl md5:d23e7d301ec57e329026814417577ee3 314.5 MB Download hmpa_function_deepfri_cellular_component.pkl md5:af66e0f852e7688342eee64f40396a43 550.0 MB Download hmpa_function_deepfri_molecular_function.pkl md5:d9aa8edaa820cce5856368672948d690 100.6 MB Download hmpa_pancreatic_cancer_gse49641_deg.csv md5:d50a560afbf8e964b8595716826822b4 55.3 MB Preview Download hmpa_pathogenicity_esm2_scores.csv md5:93f8fa8081c71819c3a62675c3785a79 14.0 MB Preview Download hmpa_sequence_clusters_esm2_leiden.csv md5:c632c4604539b08f05c268372e0cfc6b 10.6 MB Preview Download hmpa_structure_alphafold_scores.csv md5:aece04ee2bc1778ce077ca239a2f9df3 146.2 MB Preview Download hmpa_structure_classification.csv md5:842ba20110e205ae0d33c79de3056fc5 45.2 MB Preview Download hmpa_structure_clusters_foldseek.tsv md5:4bd191f6c2233ab7ef85d79171b13221 14.6 MB Download hmpa_subcellular_localization_locpro.json md5:ba74487d79d84dc1ac833553ff3ec2fe 197.2 MB Preview Download 115 Views 236 Downloads Show more details All versions This version Views Total views 115 115 Downloads Total downloads 236 236 Data volume Total data volume 86.6 GB 86.6 GB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Details DOI DOI Badge DOI 10.5281/zenodo.19547725 Markdown [](https://doi.org/10.5281/zenodo.19547725) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19547725.svg :target: https://doi.org/10.5281/zenodo.19547725 HTML <a href="https://doi.org/10.5281/zenodo.19547725"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19547725.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19547725.svg Target URL https://doi.org/10.5281/zenodo.19547725 Resource type Journal article Publisher Zenodo Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created April 13, 2026 Modified May 15, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies