Dopamine synchronizes hippocampal-prefrontal networks

Dopamine synchronizes hippocampal-prefrontal networks | bioRxiv Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search New Results Dopamine synchronizes hippocampal-prefrontal networks View ORCID Profile Benedito A de Oliveira-Junior , View ORCID Profile Fernando E Padovan-Neto , View ORCID Profile Nandakumar S Narayanan , View ORCID Profile Joao P Leite , View ORCID Profile Rafael N Ruggiero doi: https://doi.org/10.1101/2023.06.07.544112 Benedito A de Oliveira-Junior 1 Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School - University of São Paulo , Ribeirão Preto, SP, 14049-900, Brazil Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Benedito A de Oliveira-Junior For correspondence: benedito.oliveira{at}usp.br rnruggiero{at}unifesp.br Fernando E Padovan-Neto 2 Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto - University of São Paulo , Ribeirão Preto, SP, 14040-901, Brazil Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Fernando E Padovan-Neto Nandakumar S Narayanan 3 Department of Neurology, University of Iowa , Iowa City, IA, 52242, USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Nandakumar S Narayanan Joao P Leite 1 Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School - University of São Paulo , Ribeirão Preto, SP, 14049-900, Brazil Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Joao P Leite Rafael N Ruggiero 1 Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School - University of São Paulo , Ribeirão Preto, SP, 14049-900, Brazil 4 Department of Psychobiology, Escola Paulista de Medicina - Universidade Federal de São Paulo , São Paulo, SP, 04024-002, Brazil Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Rafael N Ruggiero For correspondence: benedito.oliveira{at}usp.br rnruggiero{at}unifesp.br Abstract Full Text Info/History Metrics Preview PDF Abstract Interactions among brain networks support cognition and behavior. Oscillatory activity may contribute to this process by coordinating distant neuronal populations. A crucial step toward elucidating brain function and its emergent properties is understanding the mechanisms that dynamically modulate functional connectivity in response to environmental challenges and physiological demands. Dopamine (DA) is well-positioned to modulate this process, given its role in altering neuronal excitability and regulating oscillatory cognitive networks, such as the hippocampus-prefrontal cortex (HPC-PFC) networks. However, it is mostly unknown how dopamine modulates HPC-PFC synchrony. Here, we recorded HPC and PFC activity in rats while manipulating dopamine levels. Our results show that dopamine dose-dependently induces HPC-PFC theta synchrony. This effect was not reproduced by selective activation of D 1 -like (SKF-38393) or D 2 -like (quinpirole) receptors, nor by the D 1 /D 2 non-selective agonist apomorphine. Thus, dopamine’s modulatory effects on HPC-PFC activity may depend on the precise interplay between dopamine receptor subtypes. Our findings provide evidence that dopaminergic neurotransmission plays a central role in regulating HPC-PFC oscillatory dynamics, specifically promoting synchronization in slow-frequency oscillations. Competing Interest Statement The authors have declared no competing interest. Footnotes Figure 1 has been updated to enhance clarity regarding the time interval between saline or drug doses, and the "brain extraction and tissue processing" section has been modified to improve clarity. Funder Information Declared Coordenação de Aperfeicoamento de Pessoal de Nível Superior, https://ror.org/00x0ma614 , 88887.469138/2019-00 Fundação de Amparo à Pesquisa do Estado de São Paulo, https://ror.org/02ddkpn78 , 25/09433-4 , 2016/17882-4 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license . Back to top Previous Next Posted April 30, 2026. Download PDF Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Share Dopamine synchronizes hippocampal-prefrontal networks Benedito A de Oliveira-Junior , Fernando E Padovan-Neto , Nandakumar S Narayanan , Joao P Leite , Rafael N Ruggiero bioRxiv 2023.06.07.544112; doi: https://doi.org/10.1101/2023.06.07.544112 Share This Article: Copy Citation Tools Dopamine synchronizes hippocampal-prefrontal networks Benedito A de Oliveira-Junior , Fernando E Padovan-Neto , Nandakumar S Narayanan , Joao P Leite , Rafael N Ruggiero bioRxiv 2023.06.07.544112; doi: https://doi.org/10.1101/2023.06.07.544112 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Neuroscience Subject Areas All Articles Animal Behavior and Cognition (8164) Biochemistry (19027) Bioengineering (15171) Bioinformatics (45807) Biophysics (22958) Cancer Biology (20248) Cell Biology (27495) Clinical Trials (138) Developmental Biology (14233) Ecology (21529) Epidemiology (2067) Evolutionary Biology (25940) Genetics (16436) Genomics (23979) Immunology (19175) Microbiology (43486) Molecular Biology (18481) Neuroscience (95839) Paleontology (717) Pathology (3064) Pharmacology and Toxicology (5253) Physiology (8339) Plant Biology (16378) Scientific Communication and Education (2123) Synthetic Biology (4675) Systems Biology (10450) Zoology (2436)

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