A Physiology-Informed Digital Twin Framework for Simulating Liver Health Progression

[2608.14969] A Physiology-Informed Digital Twin Framework for Simulating Liver Health Progression Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Computer Science > Machine Learning arXiv:2608.14969 (cs) [Submitted on 15 Aug 2026] Title: A Physiology-Informed Digital Twin Framework for Simulating Liver Health Progression Authors: Sumaiya Afroz Mila , Sandip Ray View a PDF of the paper titled A Physiology-Informed Digital Twin Framework for Simulating Liver Health Progression, by Sumaiya Afroz Mila and Sandip Ray View PDF HTML (experimental) Abstract: We present a physiology-informed digital twin of the human liver designed for longitudinal simulation of liver function and early-stage disease progression. The model, referred to as HEPATWIN, integrates key hepatic processes, including carbohydrate, lipid, and protein metabolism, bilirubin conjugation, bile production, and detoxification, within a unified systems-level framework to generate clinically observable biomarker trajectories. Unlike purely data-driven approaches, HEPATWIN incorporates mechanistic representations of liver physiology and patient-specific inputs such as diet, activity, and baseline biomarkers to simulate disease evolution over time. To ensure consistency with clinical progression patterns, we introduce a stage-transition-driven calibration mechanism that aligns simulated outputs with population-level biomarker distributions across disease stages, including NAFLD, fibrosis, and cirrhosis. Validation using the NIDDK NAFLD dataset demonstrates that HEPATWIN produces longitudinal biomarker estimates within clinically acceptable ranges and can forecast trajectories over multi-year horizons. Furthermore, simulated biomarkers retain sufficient clinical signal to support downstream NASH detection with competitive performance relative to models using ground-truth laboratory data. These results highlight the potential of physiology-informed digital twins for personalized, non-invasive diagnosis and prediction of organ health in general and liver health monitoring in particular. Comments: This paper is under review at IEEE Journal of Biomedical and Health Informatics (JBHI) Subjects: Machine Learning (cs.LG) Cite as: arXiv:2608.14969 [cs.LG] (or arXiv:2608.14969v1 [cs.LG] for this version) https://doi.org/10.48550/arXiv.2608.14969 Focus to learn more arXiv-issued DOI via DataCite Submission history From: Sumaiya Afroz Mila [ view email ] [v1] Sat, 15 Aug 2026 01:40:04 UTC (10,455 KB) Full-text links: Access Paper: View a PDF of the paper titled A Physiology-Informed Digital Twin Framework for Simulating Liver Health Progression, by Sumaiya Afroz Mila and Sandip Ray View PDF HTML (experimental) TeX Source view license Current browse context: cs.LG < prev | next > new | recent | 2026-08 Change to browse by: cs References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... BibTeX formatted citation × loading... 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