First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks

[2501.09087] First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Physics > Biological Physics arXiv:2501.09087 (physics) [Submitted on 15 Jan 2025 ( v1 ), last revised 16 Aug 2026 (this version, v3)] Title: First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks Authors: D. Evan Piephoff , Jianshu Cao View a PDF of the paper titled First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks, by D. Evan Piephoff and Jianshu Cao View PDF HTML (experimental) Abstract: Using a pathway analysis technique, a dynamic fluctuation relation is derived for a kinetically cooperative biomolecular machine (e.g., an enzyme or a motor protein). This new relation indicates that, in the absence of hidden current, a fluctuation theorem can be established for the first-passage time of the observable process, and we show that this dramatic reduction is a general feature applicable to a wide variety of cooperative networks. This first-passage time fluctuation theorem can be experimentally tested, with its violation serving as a unique signature of hidden detailed balance breaking. Additionally, we obtain a remarkably compact exact expression for the integrated correction to this fluctuation theorem, as well as the general form, revealing a thermodynamic bound on the kinetic branching ratio (i.e., the forward-to-backward observable process probability ratio). These results provide detailed insight into the rich connections between dynamic measurements and the underlying nonequilibrium thermodynamics for cooperative biomolecular machines. Subjects: Biological Physics (physics.bio-ph) ; Chemical Physics (physics.chem-ph); Molecular Networks (q-bio.MN) Cite as: arXiv:2501.09087 [physics.bio-ph] (or arXiv:2501.09087v3 [physics.bio-ph] for this version) https://doi.org/10.48550/arXiv.2501.09087 Focus to learn more arXiv-issued DOI via DataCite Submission history From: Daniel Piephoff [ view email ] [v1] Wed, 15 Jan 2025 19:13:39 UTC (162 KB) [v2] Fri, 12 Sep 2025 06:30:02 UTC (901 KB) [v3] Sun, 16 Aug 2026 18:57:22 UTC (1,119 KB) Full-text links: Access Paper: View a PDF of the paper titled First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks, by D. Evan Piephoff and Jianshu Cao View PDF HTML (experimental) TeX Source view license Ancillary-file links: Ancillary files ( details ) : supporting-info.pdf Current browse context: physics.bio-ph < prev | next > new | recent | 2025-01 Change to browse by: physics physics.chem-ph q-bio q-bio.MN References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... BibTeX formatted citation × loading... Data provided by: Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer ( What is the Explorer? ) Connected Papers Toggle Connected Papers ( What is Connected Papers? ) Litmaps Toggle Litmaps ( What is Litmaps? ) scite.ai Toggle scite Smart Citations ( What are Smart Citations? ) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv ( What is alphaXiv? ) Links to Code Toggle CatalyzeX Code Finder for Papers ( What is CatalyzeX? ) DagsHub Toggle DagsHub ( What is DagsHub? ) GotitPub Toggle Gotit.pub ( What is GotitPub? ) Huggingface Toggle Hugging Face ( What is Huggingface? ) ScienceCast Toggle ScienceCast ( What is ScienceCast? ) Demos Demos Replicate Toggle Replicate ( What is Replicate? ) Spaces Toggle Hugging Face Spaces ( What is Spaces? ) Spaces Toggle TXYZ.AI ( What is TXYZ.AI? ) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower ( What are Influence Flowers? ) Core recommender toggle CORE Recommender ( What is CORE? ) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs . Which authors of this paper are endorsers? | Disable MathJax ( What is MathJax? ) We gratefully acknowledge support from our major funders , member institutions , , and all contributors. About · Help · Contact · Subscribe · Copyright · Privacy · Accessibility · Operational Status (opens in new tab) Major funding support from

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