Coat stiffening can explain invagination of clathrin-coated membranes

[2405.02820] Coat stiffening can explain invagination of clathrin-coated membranes Skip to main content Search Submit Donate Log in Quantitative Biology > Subcellular Processes arXiv:2405.02820 (q-bio) [Submitted on 5 May 2024 ( v1 ), last revised 19 Sep 2024 (this version, v2)] Title: Coat stiffening can explain invagination of clathrin-coated membranes Authors: Felix Frey (IST Austria), Ulrich S. Schwarz (Heidelberg University) View PDF HTML (experimental) Abstract: Clathrin-mediated endocytosis is the main pathway used by eukaryotic cells to take up extracellular material, but the dominant physical mechanisms driving this process are still elusive. Recently several high-resolution imaging techniques have been used on different cell lines to measure the geometrical properties of clathrin-coated pits over their whole lifetime. Here we first show that the combination of all datasets with the recently introduced cooperative curvature model defines a consensus pathway, which is characterized by a flat to-curved transition at finite area, followed by linear growth and subsequent saturation of curvature. We then apply an energetic model for the composite of plasma membrane and clathrin coat to this consensus pathway to show that the dominant mechanism for invagination could be coat stiffening, which might originate from cooperative interactions between the different clathrin molecules and progressively drives the system towards its intrinsic curvature. Our theory predicts that two length scales determine the invagination pathway, namely the patch size at which the flat-to-curved transition occurs and the final pit radius. Comments: revtex, 13 pages, 5 figures in PDF-format Subjects: Subcellular Processes (q-bio.SC) ; Soft Condensed Matter (cond-mat.soft) Cite as: arXiv:2405.02820 [q-bio.SC] (or arXiv:2405.02820v2 [q-bio.SC] for this version) https://doi.org/10.48550/arXiv.2405.02820 Focus to learn more arXiv-issued DOI via DataCite Journal reference: Physical Review E 110, 064403 (2024) Related DOI : https://doi.org/10.1103/PhysRevE.110.064403 Focus to learn more DOI(s) linking to related resources Submission history From: Ulrich S. Schwarz [ view email ] [v1] Sun, 5 May 2024 05:51:16 UTC (2,151 KB) [v2] Thu, 19 Sep 2024 13:53:58 UTC (1,574 KB) Full-text links: Access Paper: View PDF HTML (experimental) TeX Source view license Current browse context: q-bio.SC < prev | next > new | recent | 2024-05 Change to browse by: cond-mat cond-mat.soft q-bio References & Citations SciX Google Scholar Semantic Scholar export BibTeX citation Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer ( What is the Explorer? ) Connected Papers Toggle Connected Papers ( What is Connected Papers? ) Litmaps Toggle Litmaps ( What is Litmaps? ) scite.ai Toggle scite Smart Citations ( What are Smart Citations? ) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv ( What is alphaXiv? ) Links to Code Toggle CatalyzeX Code Finder for Papers ( What is CatalyzeX? ) DagsHub Toggle DagsHub ( What is DagsHub? ) GotitPub Toggle Gotit.pub ( What is GotitPub? ) Huggingface Toggle Hugging Face ( What is Huggingface? ) ScienceCast Toggle ScienceCast ( What is ScienceCast? ) Demos Demos Replicate Toggle Replicate ( What is Replicate? ) Spaces Toggle Hugging Face Spaces ( What is Spaces? ) Spaces Toggle TXYZ.AI ( What is TXYZ.AI? ) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower ( What are Influence Flowers? ) Core recommender toggle CORE Recommender ( What is CORE? ) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs . Which authors of this paper are endorsers? | Disable MathJax ( What is MathJax? ) We gratefully acknowledge support from our major funders , member institutions , and all contributors. About · Help · Contact · Subscribe · Copyright · Privacy · Accessibility · Operational Status (opens in new tab)

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