Single image sensorless adaptive optics using phase-diversified multifocal array

[2509.17869] Single image sensorless adaptive optics using phase-diversified multifocal array Skip to main content Search Submit Donate Log in Physics > Optics arXiv:2509.17869 (physics) [Submitted on 22 Sep 2025 ( v1 ), last revised 27 Aug 2026 (this version, v2)] Title: Single image sensorless adaptive optics using phase-diversified multifocal array Authors: Biwei Zhang , Qi Hu , Jingyu Wang , Martin J. Booth View PDF Abstract: Image-based sensorless adaptive optics is commonly used to improve microscope image quality through aberration compensation. However, its sequential nature leads to repeated sample exposures and a prolonged aberration estimation and correction process. In this work, we used a phase-diversified foci array to enhance the aberration-related information in multi-photon fluorescence microscope images. We showed that, through use of a neural network-based image processing algorithm, we can extract aberration from a single image frame. We discussed how the number of foci can affect the wavefront correction on a bead sample, and we showed that six foci, in general, perform better than two-foci or ten-foci arrangements. We also applied our technique to correct aberrations in biological samples, including a fixed brain tissue and BPAE cells slide. Subjects: Optics (physics.optics) Cite as: arXiv:2509.17869 [physics.optics] (or arXiv:2509.17869v2 [physics.optics] for this version) https://doi.org/10.48550/arXiv.2509.17869 Focus to learn more arXiv-issued DOI via DataCite Submission history From: Biwei Zhang [ view email ] [v1] Mon, 22 Sep 2025 15:06:18 UTC (602 KB) [v2] Thu, 27 Aug 2026 09:07:00 UTC (921 KB) Full-text links: Access Paper: View PDF view license Current browse context: physics.optics < prev | next > new | recent | 2025-09 Change to browse by: physics References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer ( What is the Explorer? ) Connected Papers Toggle Connected Papers ( What is Connected Papers? ) Litmaps Toggle Litmaps ( What is Litmaps? ) scite.ai Toggle scite Smart Citations ( What are Smart Citations? ) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv ( What is alphaXiv? ) Links to Code Toggle CatalyzeX Code Finder for Papers ( What is CatalyzeX? ) DagsHub Toggle DagsHub ( What is DagsHub? ) GotitPub Toggle Gotit.pub ( What is GotitPub? ) Huggingface Toggle Hugging Face ( What is Huggingface? ) ScienceCast Toggle ScienceCast ( What is ScienceCast? ) Demos Demos Replicate Toggle Replicate ( What is Replicate? ) Spaces Toggle Hugging Face Spaces ( What is Spaces? ) Spaces Toggle TXYZ.AI ( What is TXYZ.AI? ) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower ( What are Influence Flowers? ) Core recommender toggle CORE Recommender ( What is CORE? ) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs . Which authors of this paper are endorsers? | Disable MathJax ( What is MathJax? ) We gratefully acknowledge support from our major funders , member institutions , and all contributors. About · Help · Contact · Subscribe · Copyright · Privacy · Accessibility · Operational Status (opens in new tab) Major funding support from

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