The Structural Universality of Persistence Architecture: Physics, biology, cognition, evolution - and the diagnostic use in designed systems

La Profilée is a universal structural law of persistence under transformation. Its universality is not a claim about one privileged domain but an empirical regularity: the same already-proved architecture — a determinate persister with roles Frame/Module/Coupling, the existence verdict Q1 and the identity verdict Q2 (with levels Q2a/Q2b), and the integration bound IR=R/I≤1 — recurs, with identical role-structure, across independent natural domains, and is used diagnostically in designed ones. This recurrence, obtained under a strict protocol that could have failed at every domain, is the content of the claim. The paper applies one method to several domains. In each natural domain it first names the domain’s persister, imports the domain’s own antecedent identity and existence facts, and only then tests membership in the admissibility class and instantiates the roles and verdicts — never mapping La Profilée’s vocabulary onto convenient domain nouns. This is made a formal claim: the La Profilée instantiation I(D)=(F,M,K,Q1,Q2,Q2a,Q2b) of the natural domains is pairwise structurally isomorphic (same role-structure, not same mechanism), the ladder that generates the isomorphism level by level is a recursion theorem, and the protocol’s non-circularity is an elimination proof — the domain may supply only material, never the verdicts, on pain of making La Profilée eliminable. The natural realizations (physics, biology, cognition, evolution) provide verification evidence; each instance could have failed the test, and the hardest case — the identity of a fundamental particle — does fail antecedently, which (by a falsifiability theorem) is exactly what makes the positive runs evidence. Designed systems (organizations, information systems) provide diagnosis and application only, never natural-law verification. No mechanism, value, rate, substance, or timescale is transferred between domains; only the invariant role-structure is shared. The theory claim — that La Profilée is a universal structural law — is borne by LP-CORE, on which this synthesis builds transparently. What this paper adds is the demonstrated recurrence, explicit in status though not uniform in provenance: organism identity, fundamental-particle individuation, and cell division are completed, doubly counter-read runs; cognition and evolution are series-derived realizations integrated from the core derivations; and the architecture — including the integration bound IR=R/I≤1, a Core-derived component of the law — is displayed, not re-derived. The fundamental particle returns a determinate non-instantiation, showing the protocol can fail. What is not in question is the law claim (LP-CORE’s) or a universality closed by the mere definition of the shared roles.