Insight into the synthesis of warfarin and its promiscuous derivatives

Warfarin is the most widely used anticoagulant drug which reduces the risk of blood clots forming. This review aims to highlight the significant research on the synthesis of warfarin and its derivatives using numerous methods such as Michael reactions, green enantioselective, one-pot condensation, and catalytic synthesis. The synthesis of warfarin derivatives was discussed since they have proven to have higher biological activity than warfarin itself. Further, this review was carried out to figure out the shortcomings in the synthesis methods and shed light on the contribution of each research on the development and design of stereospecific synthesis of warfarin or its derivatives which were proven to be potent hits with an acceptable cost. Moreover, the contribution of some methods in green chemistry advancement has been investigated.