Astrobiology and the Transformation of Scientific Epistemology

Astrobiology occupies an unusual position within the philosophy of science. Confronted with the n = 1 problem – having only a single example of life to study – it attempts to investigate life beyond Earth while relying entirely on Earth’s biosphere as its reference point, a constraint that creates unique epistemic challenges. Unlike traditional sciences with clear predictive frameworks, astrobiology operates as what we might call a transient science: a discipline functioning without foundational certainties, relying predominantly on abductive reasoning, and confronting hypotheses that may remain untestable for decades. It is, in essence, a science of absence – of evidence, certainty, and analogy – where progress lies in refining conceptual and experimental tools to recognize unfamiliar forms of life. This positions astrobiology alongside emerging fields like artificial intelligence and cognitive science within a broader transformation of how scientific knowledge is constructed when dealing with phenomena that transcend direct empirical access.