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Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture
Human midbrain organoids (hMOs) derived from induced pluripotent stem cells provide a powerful system to model disorders involving dopamine (DA) dysfunction, including Parkinson's disease (PD) and neuropsychiatric conditions. However, current differentiation protocols still fall short in recapitulat
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