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Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis
biochemistry-and-cell-biologybiological-sciencesbiomedical-and-clinical-sciencesfibroblastsoncology-and-carcinogenesissenescence
Fibroblasts form a major component of the stroma in normal mammary tissue and breast tumors. Here, we have applied longitudinal single-cell transcriptome profiling of >45,000 fibroblasts in the mouse mammary gland across five different developmental stages and during oncogenesis. In the
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