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Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment.
Cholinergic activity supports cortical activation during REM sleep, while other neurotransmitter systems are almost silent. Here, we tested the long-standing hypothesis that early cholinergic denervation may be associated with REM sleep EEG slowing in older adults. Twenty-four older participants wit
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