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The method matters: free water imaging in Parkinson's disease is not a binary verdict

Martinez-Nunez AE et al.
Europe PMC · Papers
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biomedicallife-science
A recent comparison of neuromelanin and free water (FW) imaging in Parkinson's disease concluded that FW imaging underperforms. We argue this reflects methodological constraints, not biological truth. Three issues compromise FW sensitivity: use of a registration template that degrades substantia nig
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