Guided Tissue Regeneration in the Healing of Through and Through Lesions

Study Title: Effects of Guided Tissue Regeneration on the Healing of Through \& Through Periradicular Lesions - A Randomized Controlled Study Rationale: Through and through defects found to be difficult to heal without GTR intervention. Various studies has been done either with graft or without graft but no randomized controlled trial has been done on resorbable membrane(GTR) in through and through lesion. Aim \& Objectives: To evaluate the effect of resorbable collagen membrane in the healing of through \& through lesion. Setting: Study was conducted in Post Graduate Institute Of Dental Sciences, Rohtak in the department of Conservative Dentistry \& Endodontics. Study Design: Randomized Controlled Trial Time Frame: March 2016 to October 2017 Population / Participants: Patients of age 16 years (male/female) and above were enrolled in the study. Inclusion Criteria: Patients of age 16 years and above, -ve response to vitality test, failed previous root canal treatment with purulent discharge, failed previous surgery, recurrent episode of purulent discharge. Exclusion Criteria: Unrestorable tooth, fractured /perforated roots, serious medical illness, smokers, pregnant females and lactating mothers, grade 3 mobile teeth, the need for antibiotic prophylaxis prior to dental care. Sample size: 30 patients (15 patients in each group) Methods: Clinically and radiographically diagnosis of lesion, vitality check by EPT, preoperative evaluation by bleeding on probing, clinical attachment level, gingival marginal position \& pocket depth. Surgical procedures will be carried out under operating microscope with 8 × 16 magnification by following standardized treatment methods. Outcome measures: Follow up of patients were carried out at 3, 6, 9 \& 12 months and outcome measures were compared with same method done pre operatively and described as Complete healing, incomplete healing (scar tissue), uncertain healing, unsatisfactory healing (failure). Statistical method: Da