Dog-human gene network colocalization links synaptic signalling and ubiquitination to compulsive disorders

Obsessive-compulsive disorder (OCD) is highly polygenic, and the largest genome-wide association study (GWAS) to date — 53,660 cases and 2,044,417 controls — identified only 30 loci, a small fraction of those expected to cause disease and too few to resolve the underlying biological pathways. Some d