Nephron Sparing Renal Surgery and Total Nephrectomy

The incidence of the diagnosis of renal cell carcinoma has increased during the past two decades because of the detection of small renal tumours that occur incidentally because of increased use of CT-scanning (1,2). Postoperative renal insufficiency was a significant independent predictor of overall and cardiovascular specific survival (3). "Nephron-sparing" surgical techniques are now preferred for small tumor masses and laparoscopic intervention is replacing open surgery at centers that master this technique. This is an area of priority within the Regions of Zaeland and Southern Denmark. The primary endpoint is: The early plasma (5 days) \[NT-proBNP\] response predicts long-term total renal function and function of the remaining kidney. The second endpoint: Plasma \[NT-proBNP\] increases acutely after partial nephrectomy and the change reflects the renal mass reduction. Chronic blood pressure change is inversely related to plasma \[BNP\].