HAL (France)
open access
Liver sinusoidal endothelial cells and laminin dictate cholangiocytes’ fate in chronic liver disease
Background & Aims: In chronic liver diseases (CLD), when native hepatocytes enter replicative senescence, new hepatocytes are generated through differentiation of reactive cholangiocytes, also known as ductular reaction (DR). However, this mechanism alone is insufficient to prevent liver failure
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