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Deciphering the Renal tumOr microenvironment to PersonaLize immunE-targeted Treatment (DROPLET): transcriptomic profiling of primary and secondary lesions identified a potential crosstalk between MARCO+ macrophages and deregulated cancer-cell proliferation in mediating progression and therapy response of advanced renal cell carcinoта.
Immune checkpoint inhibitors (ICI) anti-programmed death-1 (αPD-1) have considerably improved the survival of patients with advanced clear cell renal cell carcinoma (ccRCC). However, a high number of patients fails to respond to ICI. Recent studies identified M2 macrophages (Mφs) as key players of c
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