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Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease

Juan Pablo Romero. MD, PhD · 2024
ClinicalTrials.gov · Datasets · License: Public Domain · 2024
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neuropsychologyparkinson-disease
The goal of this observational study is to describe non motor symptoms in a prospective study of patients with Parkinson's disease associated to glucocerebrosidase (GBA-PD) mutations. The main questions it aims to answer are: * Do GBA-PD patients have a greater burden of non motor symptoms? * How do these non motor symptoms evolve during a prospective follow up of two years? * Are these non motor symptoms different from those that affect Parkinson's disease patients without glucocerebrosidase mutations (non GBA-PD), in prevalence, severity and type? * Do these non motor symptoms correlate with objective measures such as posturography or speed reaction tests? * Is there a test or combination of tests that can predict the appearance of early or severe non motor symptoms? For this reason researchers will compare the GBA-PD group of patients with a group of non mutated GBA Parkinson disease. Participants will undergo a neurological and neuropsychological evaluation with different tests in subsequent visits for a total of 2 years.
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