Colorectal Cancer Immunomonitoring Combined With Radiofrequency ablatIon

The primary objective of the study aims to compare soluble CD154 (CD40L) levels before and after radiofrequency ablation (RFA) in patients with colorectal cancer (CRC) liver metastases. The secondary objectives aims: * to compare soluble CD154 (sCD40-L) levels before and after treatment by RFA or surgery alone in patients with CRC liver metastases; * to study the feasibility and reliability of soluble CD154 (sCD40-L) levels to detect and quantify the induction of immun response in CRC liver metastases patients after RFA; * to study the impact of surgery on plasma soluble CD154 levels; * to study association between CD154 expression level before and after RFA in CRC liver metastases patients and relapses rate at 1 year.