REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)

This is a multi-centre, multi-national, prospective, observational study of Huntington's disease (HD) with a control group of volunteers to: * obtain natural history data on many HD mutation carriers and individuals who are part of an HD family * relate phenotypical characteristics (genetic modifiers / wet and dry biomarkers) * expedite identification and recruitment of participants for clinical trials * develop and validate sensitive and reliable outcome measures for detecting onset and change over the natural course of premanifest and manifest HD which may also be potential outcome measures for use in future clinical trials and clinical care * plan for future research studies