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A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

Blueprint Medicines Corporation · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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advanced-solid-tumorcolorectal-neoplasmsnon-small-cell-lung-cancerpancreatic-ductal-adenocarcinoma
A first in human study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of BLU-924 / SAR449336, a pan-KRAS inhibitor, in participants with advanced Pancreatic Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer harboring KRAS mutations.
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