Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder: A Study of Dosing With Laser

Note: This registration is retained as a historical study record. Updated study information and subsequent protocol modifications are available under ClinicalTrials.gov Identifier NCT06934135, which serves as the actively maintained study registration. The Near-Infrared Transcranial Laser Therapy (NIR-TLT) is a non-invasive intervention that delivers near-infrared light to brain tissue. Photobiomodulation is believed to interact with cytochrome c oxidase, a mitochondrial enzyme involved in cellular energy metabolism, resulting in increased adenosine triphosphate (ATP) production and potential neuroprotective effects. These mechanisms may promote cellular plasticity and support improvement of depressive symptoms. This study evaluates the safety, tolerability, and potential antidepressant effects of NIR-TLT in adults with Major Depressive Disorder.