ClinicalTrials.gov
public full text
Public Domain
Evaluation of Dose-Dependent Repeated-Dose Neramexane Effects on Cardiac Repolarisation (QT/QTc Interval Duration): Electrocardiogram (ECG) Study in Healthy Adult Subjects
Primary: * To assess the effects of ascending repeated-doses of oral \[p.o.\] neramexane at therapeutic and supra-therapeutic steady-state doses on cardiac repolarisation (QT/QTc interval) in healthy male and female subjects. Secondary: * To assess the pharmacokinetics \[PK\] of neramexane and N-OH neramexane (if a validated method will be available for this metabolite) following repeated daily doses of 50 mg (steady state), 75 mg (steady state) and 87.5 mg (steady state). * To assess the safety and tolerability of neramexane 50 mg, 62.5 mg, 75 mg and 87.5 mg repeated-dose treatments when gradually up-titrated in healthy subjects. * To assess the concentration-QT relationship.
Conceptio Open Archive
Analyze & explore related research in Conceptio
Connect this record directly into your research workflow or AI agent. Explore citations across open repositories, query full text, and export structured proof bundles.
This document is indexed with metadata only: full text is not available in the archive for this record. Open the official source ↗
Related documents
- QTc Study GSK573719+GW642444#1093478
- Evaluation of Possible Effects on the QTc Interval of CHF 4226 pMDI in Healthy Volunteers#875545
- Trial of Epinephrine and Albuterol in Bronchiolitis#1171023
- A Multiple Dose Pharmacokinetic Study of Perampanel in Korean Healthy Subjects#825428
- A Phase 1 QT Study in Healthy Male Subjects#895806
Record · ID 842451
Retrieved via Conceptio: every document is proof-bundled with source, license, and retrieval metadata.
Retrieved via Conceptio: every document is proof-bundled with source, license, and retrieval metadata.
Bring this data into your agent: Connect via MCP or API · 20 free credits to start · no card required
Read the Docs → · View CLI source on GitHub · Conceptio Open Knowledge Archive
Read the Docs → · View CLI source on GitHub · Conceptio Open Knowledge Archive