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Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype

University of North Carolina, Greensboro · 2019
ClinicalTrials.gov · Datasets · License: Public Domain · 2019
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alzheimeralzheimer-diseasealzheimer-sdementiaexercisehealthynaphysical-activity
Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.
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