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Effect of Probenecid on Pexidartinib Pharmacokinetics

Daiichi Sankyo · 2017
ClinicalTrials.gov · Datasets · License: Public Domain · 2017
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The primary objective of this trial is to assess the effect of probenecid on the pharmacokinetics (PK) of single-dose pexidartinib in healthy subjects. Secondary objectives are to assess the safety and tolerability of pexidartinib alone and in combination with probenecid. Participants will be confined to the clinic for approximately 32 days. Blood samples will be collected for PK analysis of pexidartinib and metabolites at predose and up to 312 hours (h) post dose.
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