Loneliness and Occurrence of Suicide Attempts and Suicidal Ideas

Suicide is a major health problem that causes annually a million death worldwide. Loneliness is known to be associated with suicidal ideation in minors and to be related with suicidal risk in elderly people. However little is known about this association in a middle-aged population. Loneliness is a modifiable factor with suitable psychotherapeutic measures, it is essential to improve the scientific and medical knowledge about the link between this feeling and suicide risk in a population of depressed patients in middle age. The main objective is the study of the relationship between loneliness and the occurrence of suicidal behavior (SB) in major depressed adult population over 12 months. The secondary objectives are: * Identification of risk factors (clinical, neuropsychological and biological) of the occurrence of SB within a clinical population and their interaction; * Identification of predictive factors (clinical, neuropsychological, biological) therapeutic response to antidepressant in the context of depression.