AMD Phenotype and Genotype Study

Background: \- Age-related macular degeneration (AMD) is a disease that blurs the sharp vision needed for activities such as reading, sewing, and driving. It affects the macula, the center of the retina at the back of the eye, which allows a person to see fine detail. Researchers want to collect medical histories, eye exam data, and genetic information that may be associated with AMD. They want to compare this information with information collected from people without AMD. Objectives: \- To collect medical information and gene samples for researchers studying AMD. Eligibility: * Individuals between and 60 and 90 years of age who have AMD in at least one eye. * Individuals between and 60 and 90 years of age who have no AMD in either eye. Design: * This study will involve one study visit. This study visit will last 6 to 8 hours. * Participants will have the following tests and exams as part of their study visit: * Full physical exam and medical history * Full eye examination * Laser scan of the eye * Retina function test * Vision sensitivity test * Optional blood sample (for genetic study) * No treatment will be provided as part of this study.