The Effect of Physical Activity on Bone Mineralization and Immune System in Very Low Birth Weight Infants

Studies have demonstrated that brief (5-10 min a day) passive range-of-motion exercise is beneficial for bone development in very low birth weight (VLBW) preterm infants. However, the optimal duration and frequency of exercise for bone development in preterm infants is yet unknown. The effect of exercise on the immune system was widely studied in adult and children. Exercise induces increase in IL-6, IL-10, and IL1ra. In adult even 10 minutes of flexion and extension of the wrist cause systemic increase in IL-6. The effect of physical activity on pro and anti inflammatory cytokines in preterm infant was not studied. Objectives: 1. To assess weather twice daily exercise intervention will enhance bone strength compared to once a day intervention 2. To evaluate the effect of a single exercise intervention on inflammatory mediators. Methods: Single center (Meir Medical Center), double blind, randomized control study.