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Neoadjuvant Treatment of Ovarian Cancer With Fuzuloparib in Combination With Apatinib

Cancer Institute and Hospital, Chinese Academy of Medical Sciences · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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neoadjuvant-therapyovarian-cancertargeted-therapy
In this study, investigators propose to use fuzuloparib and apatinib as neoadjuvant therapy for Homologous recombination deficiency (HRD)positive advanced ovarian cancer patients, aiming to explore the efficacy and safety of this 'de-chemotherapy' regimen as neoadjuvant therapy for advanced ovarian cancer, and to conduct genetically related subgroup analyses, to guide the precision therapy and provide a new therapeutic option for HRD-positive patients with advanced ovarian cancer. To provide a new treatment option In order to increase the R0 resection rate of surgery and reduce chemotherapy resistance, thus improving the prognosis and prolonging the survival of patients.
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