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Phase III Randomized, Double-Blind Study of Prednisone for Duchenne Muscular Dystrophy

National Center for Research Resources (NCRR) · 1995
ClinicalTrials.gov · Datasets · License: Public Domain · 1995
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duchenne-muscular-dystrophy
OBJECTIVES: I. Characterize the effect of prednisone on muscle protein metabolism in patients with Duchenne muscular dystrophy. II. Determine whether prednisone changes levels of insulin-like growth factor 1, growth hormone, and insulin. III. Characterize the effect of prednisone on muscle morphometry and muscle localization of utrophin. IV. Compare the prednisone response in patients with Duchenne muscular dystrophy to that seen in normal individuals and in patients with facioscapulohumeral dystrophy.
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