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D2C7-IT + 2141-V11 Combination Post-resection in rGBM

Darell Bigner · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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glioblastoma
The purpose of this study is to assess the safety and efficacy of the combination of D2C7-IT+2141-V11 administered in the non-enhancing tumor of patients with resected recurrent glioblastoma (rGBM) via convection enhanced delivery (CED), followed by subcutaneous cervical perilymphatic injections (CPLIs) of 2141-V11 2 and 4 weeks post infusion, then every 3 weeks for a year, and every 4-6 weeks thereafter if patients benefit from therapy.
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