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Pan European Collaboration on Antipsychotic Naive Schizophrenia (PECANS)

University of Copenhagen · 2008
ClinicalTrials.gov · Datasets · License: Public Domain · 2008
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cognitiondopaminefmrimrirewardschizophrenia
The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology. Additionally, the investigators want to examine the influence of D2 receptor blockade on these disturbances. The investigators expect disturbances in the dopaminergic system at baseline to correlate with specific structural and functional changes and with disruption in information processing as measured with psychophysiological and neurocognitive methods - and investigators expect D2 receptor blockade to reverse some of the functional and cognitive impairments.
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